{"product_id":"fkbp12-protac-dtag-13-dtag-13-1-mg","title":"FKBP12 PROTAC dTAG-13 (dTAG-13) 1 mg","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cstrong\u003e\u003cspan\u003edTAG-13\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e is a heterobifunctional PROTAC research reagent for rapid, controlled degradation of proteins fused to the engineered FKBP12^F36V^ tag. One end of the molecule binds FKBP12^F36V^; the other recruits the cereblon (CRBN) E3 ubiquitin ligase complex. This brings the tagged protein to the ubiquitin–proteasome pathway for degradation. \u003cmeta charset=\"utf-8\"\u003eBy introducing the FKBP12^F36V^ tag to a protein of interest, researchers can use dTAG-13 to study the effects of acute protein loss. Applications include target validation, pathway analysis, and studies of protein function in cells. \u003cstrong\u003eThe protein must carry the FKBP12^F36V^ tag\u003c\/strong\u003e for the intended dTAG response; dTAG-13 is not a general degrader of untagged FKBP12.\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eProduct detail\u003c\/th\u003e\n\u003cth\u003eDescription\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eTargeting system\u003c\/td\u003e\n\u003ctd\u003eFKBP12^F36V^ tagged proteins\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eRecruited E3 ligase\u003c\/td\u003e\n\u003ctd\u003eCereblon (CRBN)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMechanism\u003c\/td\u003e\n\u003ctd\u003eInduced ubiquitination and proteasomal degradation\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula\u003c\/td\u003e\n\u003ctd\u003eC₅₇H₆₈N₄O₁₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular weight\u003c\/td\u003e\n\u003ctd\u003e1049.18 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eIntended use\u003c\/td\u003e\n\u003ctd\u003eResearch use only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e","brand":"Cheminpharma","offers":[{"title":"Default Title","offer_id":50316098896010,"sku":null,"price":250.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0565\/5137\/4986\/files\/dTAG13-001.webp?v=1790627467","url":"https:\/\/cheminpharma.com\/products\/fkbp12-protac-dtag-13-dtag-13-1-mg","provider":"Cheminpharma","version":"1.0","type":"link"}